Adenovirus 5-vectored P. falciparum vaccine expressing CSP and AMA1. Part A: safety and immunogenicity in seronegative adults.-论文-万方医学网

作者： Martha,Sedegah ^[1] ; Cindy,Tamminga ; Shannon,McGrath ; Brent,House ; Harini,Ganeshan ; Jennylynn,Lejano ; Esteban,Abot ; Glenna J,Banania ; Renato,Sayo ; Fouzia,Farooq ; Maria,Belmonte ; Nalini,Manohar ; Nancy O,Richie ; Chloe,Wood ; Carole A,Long ; David,Regis ; Francis T,Williams ; Meng,Shi ; Ilin,Chuang ; Michele,Spring ; Judith E,Epstein ; Jose,Mendoza-Silveiras ; Keith,Limbach ; Noelle B,Patterson ; Joseph T,Bruder ; Denise L,Doolan ; C Richter,King ; Lorraine,Soisson ; Carter,Diggs ; Daniel,Carucci ; Sheetij,Dutta ; Michael R,Hollingdale ; Christian F,Ockenhouse ; Thomas L,Richie

作者单位： U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America. Martha.Sedegah@med.navy.mil ^[1]

主题词腺病毒科(Adenoviridae);青少年(Adolescent);成年人(Adult);抗原, 原虫(Antigens, Protozoan);CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);剂量效应关系, 免疫(Dose-Response Relationship, Immunologic);女(雌)性(Female);基因表达(Gene Expression);遗传载体(Genetic Vectors);人类(Humans);免疫, 细胞(Immunity, Cellular);免疫, 体液(Immunity, Humoral);干扰素γ(Interferon-gamma);疟疾疫苗(Malaria Vaccines);男(雄)性(Male);膜蛋白质类(Membrane Proteins);中年人(Middle Aged);肽碎片(Peptide Fragments);恶性疟原虫(Plasmodium falciparum);原虫蛋白质类(Protozoan Proteins);青年人(Young Adult)

DOI 10.1371/journal.pone.0024586

PMID 22003383

发布时间 2021-10-20

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Adenovirus 5-vectored P. falciparum vaccine expressing CSP and AMA1. Part A: safety and immunogenicity in seronegative adults.

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Adenovirus 5-vectored P. falciparum vaccine expressing CSP and AMA1. Part A: safety and immunogenicity in seronegative adults.

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PloS one

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