换一批
换一批Activation of the c-Jun N-terminal kinase/activating transcription factor 3 (ATF3) pathway characterizes effective arylated diazeniumdiolate-based nitric oxide-releasing anticancer prodrugs.
作者：
主题词
转录激活因子3(Activating Transcription Factor 3);动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);细胞分裂(Cell Division);细胞系, 肿瘤(Cell Line, Tumor);酶激活(Enzyme Activation);G2期(G2 Phase);基因沉默(Gene Silencing);人类(Humans);JNK丝裂原活化蛋白激酶类(JNK Mitogen-Activated Protein Kinases);肺肿瘤(Lung Neoplasms);小鼠(Mice);小鼠, 裸(Mice, Nude);一氧化氮供体(Nitric Oxide Donors);哌嗪类(Piperazines);药物前体(Prodrugs);信号传导(Signal Transduction);构效关系(Structure-Activity Relationship);增量调节(Up-Regulation);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1021/jm2004128
PMID
22003962
发布时间
2024-06-15
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