换一批A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies.
第一作者：
Gabriele,Schaefer
第一单位：
Department of Research Oncology, Genentech, Inc, South San Francisco, CA 94080, USA.
作者：
医学主题词
动物(Animals);抗体, 双特异性(Antibodies, Bispecific);抗体, 单克隆(Antibodies, Monoclonal);抗体特异性(Antibody Specificity);抗肿瘤药(Antineoplastic Agents);结合部位, 抗体(Binding Sites, Antibody);结合, 竞争性(Binding, Competitive);结晶学, X线(Crystallography, X-Ray);药物评价, 临床前(Drug Evaluation, Preclinical);抗药性, 肿瘤(Drug Resistance, Neoplasm);女(雌)性(Female);人类(Humans);免疫球蛋白G(Immunoglobulin G);MAP激酶信号系统(MAP Kinase Signaling System);成束猴(Macaca fascicularis);小鼠(Mice);磷酰化(Phosphorylation);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);信号传导(Signal Transduction)
DOI
10.1016/j.ccr.2011.09.003
PMID
22014573
发布时间
2020-12-19
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Cancer cell
472-86页
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