The LMP7-K allele of the immunoproteasome exhibits reduced transcript stability and predicts high risk of colon cancer.
作者:
主题词
ATP结合匣式转运子(ATP-Binding Cassette Transporters);成年人(Adult);老年人(Aged);等位基因(Alleles);Caco-2细胞(Caco-2 Cells);细胞系, 肿瘤(Cell Line, Tumor);结肠肿瘤(Colonic Neoplasms);结直肠肿瘤(Colorectal Neoplasms);半胱氨酸内肽酶类(Cysteine Endopeptidases);女(雌)性(Female);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);基因频率(Gene Frequency);基因, MHCⅠ类(Genes, MHC Class I);疾病遗传易感性(Genetic Predisposition to Disease);基因型(Genotype);HLA-B抗原(HLA-B Antigens);HT29细胞(HT29 Cells);人类(Humans);免疫遗传学(Immunogenetics);干扰素γ(Interferon-gamma);男(雄)性(Male);多态现象, 遗传(Polymorphism, Genetic);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);RNA, 信使(RNA, Messenger)
DOI
10.1158/0008-5472.CAN-10-1883
PMID
22037870
发布时间
2018-12-01
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Cancer research
7145-54页
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