Functionally enhanced siRNA targeting TNFα attenuates DSS-induced colitis and TLR-mediated immunostimulation in mice.
第一作者:
Sandra M,Ocampo
第一单位:
Institute for Advanced Chemistry of Catalonia (IQAC), Spanish Research Council (CSIC), Barcelona, Spain.
作者:
主题词
动物(Animals);细胞系(Cell Line);聚类分析(Cluster Analysis);硫酸葡聚糖(Dextran Sulfate);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);基因表达谱(Gene Expression Profiling);基因表达调控(Gene Expression Regulation);人类(Humans);免疫, 先天(Immunity, Innate);炎性肠疾病(Inflammatory Bowel Diseases);巨噬细胞(Macrophages);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);RNA, 小分子干扰(RNA, Small Interfering);信号传导(Signal Transduction);Toll样受体(Toll-Like Receptors);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)
DOI
10.1038/mt.2011.236
PMID
22044934
发布时间
2021-10-20
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Molecular therapy
382-90页
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