Cofilin-mediated F-actin severing is regulated by the Rap GTPase and controls the cytoskeletal dynamics that drive lymphocyte spreading and BCR microcluster formation.
第一作者:
Spencer A,Freeman
第一单位:
Department of Microbiology and Immunology, I³ and Cell and Developmental Biology Research Groups, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
作者:
主题词
肌动蛋白解聚因子类(Actin Depolymerizing Factors);肌动蛋白类(Actins);动物(Animals);抗原呈递(Antigen Presentation);B-淋巴细胞(B-Lymphocytes);趋化性, 白细胞(Chemotaxis, Leukocyte);细胞骨架(Cytoskeleton);树突细胞(Dendritic Cells);荧光抗体技术(Fluorescent Antibody Technique);GTP磷酸水解酶类(GTP Phosphohydrolases);免疫印迹法(Immunoblotting);淋巴细胞活化(Lymphocyte Activation);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);多基因族(Multigene Family);受体, 抗原, B细胞(Receptors, Antigen, B-Cell);T淋巴细胞(T-Lymphocytes);转染(Transfection)
DOI
10.4049/jimmunol.1102233
PMID
22068232
发布时间
2011-11-21
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