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Inhibition of hematopoietic protein tyrosine phosphatase augments and prolongs ERK1/2 and p38 activation.

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第一作者： Eduard,Sergienko

第一单位： Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, United States.

作者： Eduard,Sergienko ^[1] ; Jian,Xu ; Wallace H,Liu ; Russell,Dahl ; David A,Critton ; Ying,Su ; Brock T,Brown ; Xochella,Chan ; Li,Yang ; Ekaterina V,Bobkova ; Stefan,Vasile ; Hongbin,Yuan ; Justin,Rascon ; Sharon,Colayco ; Shyama,Sidique ; Nicholas D P,Cosford ; Thomas D Y,Chung ; Tomas,Mustelin ; Rebecca,Page ; Paul J,Lombroso ; Lutz,Tautz

作者单位： Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, United States. ^[1]

医学主题词动物(Animals);细胞系(Cell Line);酶激活(Enzyme Activation);酶抑制剂(Enzyme Inhibitors);人类(Humans);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);丝裂原活化蛋白激酶1(Mitogen-Activated Protein Kinase 1);丝裂原活化蛋白激酶3(Mitogen-Activated Protein Kinase 3);模型, 分子(Models, Molecular);蛋白质酪氨酸磷酸酶类(Protein Tyrosine Phosphatases);构效关系(Structure-Activity Relationship);T淋巴细胞(T-Lymphocytes);p38丝裂原活化蛋白激酶类(p38 Mitogen-Activated Protein Kinases)

DOI 10.1021/cb2004274

PMID 22070201

发布时间 2025-05-29

基金项目

U54 HG005033/HG/NHGRI NIH HHS/United States R01 MH52711/MH/NIMH NIH HHS/United States R21 CA132121/CA/NCI NIH HHS/United States 1R21 CA132121/CA/NCI NIH HHS/United States R03 MH084230/MH/NIMH NIH HHS/United States X01MH077603/MH/NIMH NIH HHS/United States X01 MH077603/MH/NIMH NIH HHS/United States R01 MH052711/MH/NIMH NIH HHS/United States R01 MH091037/MH/NIMH NIH HHS/United States

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