换一批(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent γ-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction.
第一作者：
Yue,Pan
第一单位：
Department of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, Illinois 60208-3113, United States.
作者：
主题词
4-氨基丁酸转氨酶(4-Aminobutyrate Transaminase);动物(Animals);生物利用度(Biological Availability);羧酸类(Carboxylic Acids);可卡因相关性障碍(Cocaine-Related Disorders);环戊烷类(Cyclopentanes);狗(Dogs);多巴胺(Dopamine);视网膜电描记术(Electroretinography);女(雌)性(Female);GABA质膜转运蛋白质类(GABA Plasma Membrane Transport Proteins);GABA摄取抑制剂(GABA Uptake Inhibitors);人类(Humans);男(雄)性(Male);小鼠(Mice);微透析(Microdialysis);伏核(Nucleus Accumbens);卵母细胞(Oocytes);正电子发射断层显像术(Positron-Emission Tomography);脯氨酸(Proline);放射配体测定(Radioligand Assay);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);大鼠, Wistar(Rats, Wistar);受体, GABA(Receptors, GABA);视网膜(Retina);立体异构现象(Stereoisomerism);组织分布(Tissue Distribution);氨己烯酸(Vigabatrin);光滑爪蟾(Xenopus laevis)
DOI
10.1021/jm201231w
PMID
22128851
发布时间
2025-05-29
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