Discovery of potential M2 channel inhibitors based on the amantadine scaffold via virtual screening and pharmacophore modeling.
作者:
主题词
金刚烷胺(Amantadine);抗病毒药(Antiviral Agents);结合部位(Binding Sites);药物评价, 临床前(Drug Evaluation, Preclinical);氢键合(Hydrogen Bonding);流感病毒A型, H1N1亚型(Influenza A Virus, H1N1 Subtype);流感病毒A型, H3N2亚型(Influenza A Virus, H3N2 Subtype);膜转运调节因子(Membrane Transport Modulators);模型, 分子(Models, Molecular);金刚乙胺(Rimantadine);构效关系(Structure-Activity Relationship);热力学(Thermodynamics);用户计算机接口(User-Computer Interface);病毒基质蛋白质类(Viral Matrix Proteins)
DOI
10.3390/molecules161210227
PMID
22158591
发布时间
2021-10-21
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Molecules (Basel, Switzerland)
10227-55页
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