换一批MicroRNA-1 and -133 increase arrhythmogenesis in heart failure by dissociating phosphatase activity from RyR2 complex.
第一作者：
Andriy E,Belevych
第一单位：
The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States of America.
作者：
医学主题词
动物(Animals);心律失常, 心性(Arrhythmias, Cardiac);钙(Calcium);催化作用(Catalysis);催化域(Catalytic Domain);狗(Dogs);电生理学(Electrophysiology);基因, 报告(Genes, Reporter);心力衰竭(Heart Failure);心室(Heart Ventricles);人类(Humans);异丙肾上腺素(Isoproterenol);微RNAs(MicroRNAs);模型, 生物学(Models, Biological);肌细胞(Muscle Cells);磷酸单酯水解酶类(Phosphoric Monoester Hydrolases);磷酰化(Phosphorylation);RNA, 信使(RNA, Messenger);受体, 肾上腺素能β(Receptors, Adrenergic, beta);兰尼碱受体钙释放通道(Ryanodine Receptor Calcium Release Channel);肌浆网(Sarcoplasmic Reticulum)
DOI
10.1371/journal.pone.0028324
PMID
22163007
发布时间
2021-10-21
基金项目
HL089836/HL/NHLBI NIH HHS/United States
5T32HL094300/HL/NHLBI NIH HHS/United States
HL074045/HL/NHLBI NIH HHS/United States
R21 HD058997/HD/NICHD NIH HHS/United States
T32 HL094300/HL/NHLBI NIH HHS/United States
R01 HL048848/HL/NHLBI NIH HHS/United States
R01 HL074045/HL/NHLBI NIH HHS/United States
R01 HL089836/HL/NHLBI NIH HHS/United States
R29 HL048848/HL/NHLBI NIH HHS/United States
HD058997/HD/NICHD NIH HHS/United States
HL048848/HL/NHLBI NIH HHS/United States
R01 HL063043/HL/NHLBI NIH HHS/United States
HL063043/HL/NHLBI NIH HHS/United States
- 浏览90
PloS one
e28324页
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