Teasing out the role of ATP in immune responses. See referenced article, J. Biol. Chem. 2011, 286, 44776–44787. Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is phosphatidylinositol 3-kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent.
主题词
腺苷二磷酸(Adenosine Diphosphate);腺苷三磷酸(Adenosine Triphosphate);动物(Animals);自身分泌性细胞间通讯(Autocrine Communication);趋化作用(Chemotaxis);补体C5a(Complement C5a);巨噬细胞, 腹膜(Macrophages, Peritoneal);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);伪足(Pseudopodia);嘌呤能P2Y受体激动剂(Purinergic P2Y Receptor Agonists);受体, 嘌呤能P2Y12(Receptors, Purinergic P2Y12);受体, 嘌呤能P2Y2(Receptors, Purinergic P2Y2);p38丝裂原活化蛋白激酶类(p38 Mitogen-Activated Protein Kinases)
DOI
10.1074/jbc.P111.289793
PMID
22199395
发布时间
2021-10-21
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