换一批
换一批The discovery of potent, selective, and orally active pyrazoloquinolines as PDE10A inhibitors for the treatment of Schizophrenia.
第一作者：
Ginny D,Ho
第一单位：
Department of Medicinal Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, USA. ginny.ho@merck.com; ginny.ho@spcorp.com
作者：
主题词
投药, 口服(Administration, Oral);动物(Animals);结晶学, X线(Crystallography, X-Ray);地卓西平马来酸盐(Dizocilpine Maleate);剂量效应关系, 药物(Dose-Response Relationship, Drug);酶抑制剂(Enzyme Inhibitors);高通量筛选分析(High-Throughput Screening Assays);人类(Humans);模型, 分子(Models, Molecular);分子结构(Molecular Structure);磷酸二酯水解酶类(Phosphoric Diester Hydrolases);吡唑啉酮类(Pyrazolones);喹啉类(Quinolines);大鼠(Rats);精神分裂症(Schizophrenia);立体异构现象(Stereoisomerism);构效关系(Structure-Activity Relationship)
DOI
10.1016/j.bmcl.2011.11.127
PMID
22222034
发布时间
2013-11-21
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