Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair.
第一作者:
A D,Bulgar
第一单位:
Department of Medicine, Division of Hematology/Oncology, Case Western Reserve University, Cleveland, OH, USA.
作者:
医学主题词
动物(Animals);抗原, 肿瘤(Antigens, Neoplasm);抗肿瘤药(Antineoplastic Agents);细胞系, 肿瘤(Cell Line, Tumor);DNA(DNA);DNA损伤(DNA Damage);DNA修复(DNA Repair);DNA拓扑异构酶类, Ⅱ型(DNA Topoisomerases, Type II);DNA结合蛋白质类(DNA-Binding Proteins);女(雌)性(Female);基因表达(Gene Expression);基因敲除技术(Gene Knockout Techniques);谷氨酸盐类(Glutamates);鸟嘌呤(Guanine);人类(Humans);羟胺类(Hydroxylamines);小鼠(Mice);小鼠, 裸(Mice, Nude);信号传导(Signal Transduction);尿嘧啶(Uracil);尿嘧啶-DNA糖苷酶(Uracil-DNA Glycosidase);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1038/cddis.2011.135
PMID
22237209
发布时间
2024-04-04
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Cell death & disease
e252页
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