Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1.
第一作者:
A,Fassl
第一单位:
Molecular Tumor Pathology, DKFZ, Heidelberg, Germany.
作者:
医学主题词
细胞凋亡(Apoptosis);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);细胞存活(Cell Survival);抗药性, 肿瘤(Drug Resistance, Neoplasm);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);基因沉默(Gene Silencing);胶质母细胞瘤(Glioblastoma);人类(Humans);原癌基因蛋白质c-bcl-2(Proto-Oncogene Proteins c-bcl-2);原癌基因蛋白质c-raf(Proto-Oncogene Proteins c-raf);RNA加工, 转录后(RNA Processing, Post-Transcriptional);受体, Notch1(Receptor, Notch1);信号传导(Signal Transduction);转录, 遗传(Transcription, Genetic)
DOI
10.1038/onc.2011.615
PMID
22249262
发布时间
2022-03-11
- 浏览11
Oncogene
4698-708页
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