换一批p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.
第一作者：
Nhat-Tu,Le
第一单位：
University of Rochester School of Medicine and Dentistry, Aab Cardiovascular Research Institute, 601 Elmwood Avenue, Rochester, NY 14642, USA.
作者：
医学主题词
血管紧张素Ⅱ(Angiotensin II);动物(Animals);动物, 新生(Animals, Newborn);细胞凋亡(Apoptosis);结合部位(Binding Sites);结合, 竞争性(Binding, Competitive);细胞, 培养的(Cells, Cultured);cAMP应答元件调节器(Cyclic AMP Response Element Modulator);糖尿病, 实验性(Diabetes Mellitus, Experimental);酶激活(Enzyme Activation);MAP激酶激酶5(MAP Kinase Kinase 5);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);小鼠, 转基因(Mice, Transgenic);丝裂原活化蛋白激酶7(Mitogen-Activated Protein Kinase 7);心肌梗死(Myocardial Infarction);肌细胞, 心脏(Myocytes, Cardiac);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);核糖体蛋白质S6激酶类, 90-kDa(Ribosomal Protein S6 Kinases, 90-kDa);信号传导(Signal Transduction);时间因素(Time Factors);转染(Transfection);泛素蛋白连接酶类(Ubiquitin-Protein Ligases)
DOI
10.1161/CIRCRESAHA.111.254730
PMID
22267842
发布时间
2025-05-29
基金项目
R01 HL108551/HL/NHLBI NIH HHS/United States
R01 HL088400/HL/NHLBI NIH HHS/United States
R37 HL065619/HL/NHLBI NIH HHS/United States
PG/12/76/29852/BHF_/British Heart Foundation/United Kingdom
R01 HL102746/HL/NHLBI NIH HHS/United States
PG/09/052/27833/BHF_/British Heart Foundation/United Kingdom
R01 GM061728/GM/NIGMS NIH HHS/United States
R01 HL064839/HL/NHLBI NIH HHS/United States
P01 HL077789/HL/NHLBI NIH HHS/United States
R01 HL088637/HL/NHLBI NIH HHS/United States
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Circulation research
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