换一批The histone deacetylase inhibitor valproic acid lessens NK cell action against oncolytic virus-infected glioblastoma cells by inhibition of STAT5/T-BET signaling and generation of gamma interferon.
第一单位：
Medical Scientist Training Program, The Ohio State University Medical Center and The James Cancer Hospital and Solove Research Institute, Columbus, Ohio, USA.
作者：
医学主题词
动物(Animals);细胞系(Cell Line);细胞毒性, 免疫(Cytotoxicity, Immunologic);胶质母细胞瘤(Glioblastoma);组蛋白脱乙酰基酶抑制剂(Histone Deacetylase Inhibitors);人类(Humans);炎症(Inflammation);干扰素γ(Interferon-gamma);杀伤细胞, 天然(Killer Cells, Natural);小鼠(Mice);小鼠, 裸(Mice, Nude);溶瘤病毒疗法(Oncolytic Virotherapy);溶瘤病毒(Oncolytic Viruses);STAT5转录因子(STAT5 Transcription Factor);信号传导(Signal Transduction);单纯疱疹病毒属(Simplexvirus);T盒域蛋白质类(T-Box Domain Proteins);丙戊酸(Valproic Acid)
DOI
10.1128/JVI.05545-11
PMID
22318143
发布时间
2025-01-03
- 浏览15
Journal of virology
4566-77页
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