换一批
换一批Protein kinase CK2 protects multiple myeloma cells from ER stress-induced apoptosis and from the cytotoxic effect of HSP90 inhibition through regulation of the unfolded protein response.
第一作者：
Sabrina,Manni
第一单位：
Department of Medicine, University of Padova, Via Giustiniani 2, Padova 35128, Italy.
作者：
主题词
动物(Animals);细胞凋亡(Apoptosis);苯醌类(Benzoquinones);印迹法, 蛋白质(Blotting, Western);酪蛋白激酶Ⅱ(Casein Kinase II);细胞系, 肿瘤(Cell Line, Tumor);细胞, 培养的(Cells, Cultured);酶抑制剂(Enzyme Inhibitors);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);HSP90热休克蛋白质类(HSP90 Heat-Shock Proteins);人类(Humans);内酰胺类, 大环(Lactams, Macrocyclic);小鼠(Mice);小鼠, SCID(Mice, SCID);显微镜检查, 共焦(Microscopy, Confocal);多发性骨髓瘤(Multiple Myeloma);RNA干扰(RNA Interference);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);信号传导(Signal Transduction);毒胡萝卜内酯(Thapsigargin);非折叠蛋白质应答(Unfolded Protein Response);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1158/1078-0432.CCR-11-1789
PMID
22351691
发布时间
2021-12-03
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Clinical cancer research
1888-900页
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