换一批Overexpression of SKI oncoprotein leads to p53 degradation through regulation of MDM2 protein sumoylation.
第一作者：
Boxiao,Ding
第一单位：
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA.
作者：
医学主题词
细胞转化, 肿瘤(Cell Transformation, Neoplastic);DNA结合蛋白质类(DNA-Binding Proteins);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);HEK293细胞(HEK293 Cells);Hep G2细胞(Hep G2 Cells);人类(Humans);突变(Mutation);肿瘤(Neoplasms);原癌基因蛋白质类(Proto-Oncogene Proteins);原癌基因蛋白质c-mdm2(Proto-Oncogene Proteins c-mdm2);SUMO化(Sumoylation);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);泛素缀合酶类(Ubiquitin-Conjugating Enzymes)
DOI
10.1074/jbc.M111.301523
PMID
22411991
发布时间
2025-01-03
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