Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration.

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作者： Yanan,Zheng ^[1] ; Devin B,Tesar ^[1] ; Lisa,Benincosa ^[2] ; Herbert,Birnböck ^[3] ; C Andrew,Boswell ^[4] ; Daniela,Bumbaca ^[4] ; Kyra J,Cowan ^[4] ; Dimitry M,Danilenko ^[4] ; Ann L,Daugherty ^[5] ; Paul J,Fielder ^[4] ; Hans Peter,Grimm ^[3] ; Amita,Joshi ^[4] ; Nicole,Justies ^[3] ; Gerry,Kolaitis ^[2] ; Nicholas,Lewin-Koh ^[4] ; Jing,Li ^[4] ; Sami,McVay ^[4] ; Jennifer,O'Mahony ^[4] ; Michael,Otteneder ^[3] ; Michael,Pantze ^[3] ; Wendy S,Putnam ^[4] ; Zhihua J,Qiu ^[4] ; Jane,Ruppel ^[4] ; Thomas,Singer ^[3] ; Oliver,Stauch ^[3] ; Frank-Peter,Theil ^[4] ; Jennifer,Visich ^[4] ; Jihong,Yang ^[4] ; Yong,Ying ^[4] ; Leslie A,Khawli ^[4] ; Wolfgang F,Richter ^[3]

作者单位： Research and Early Development; Genentech; South San Francisco, CA USA; These authors contributed equally to this work. ^[1] Drug Metabolism and Pharmacokinetics; Pharma Research and Early Development; Hoffmann-La Roche Inc.; Nutley, NJ USA. ^[2] Pharma Research and Early Development; F. Hoffmann-La Roche Ltd.; Basel, Switzerland. ^[3] Research and Early Development; Genentech; South San Francisco, CA USA. ^[4] Drug Delivery, Pharma Technical Development; Genentech; South San Francisco, CA USA. ^[5]

关键词 animal model mAb IgG minipig neonatal Fc receptor (FcRn)pharmacokinetics subcutaneous bioavailability

主题词动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);女(雌)性(Female);人类(Humans);注射, 皮下(Injections, Subcutaneous);男(雄)性(Male);模型, 免疫学(Models, Immunological);猪(Swine);猪, 雏型(Swine, Miniature)

DOI 10.4161/mabs.4.2.19387

PMID 22453096

发布时间 2021-10-21

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Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration.

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Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration.

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