换一批
换一批Effects of culture duration on gene expression of P450 isoforms, uptake and efflux transporters in primary hepatocytes cultured in the absence and presence of interleukin-6: implications for experimental design for the evaluation of downregulatory effects of biotherapeutics.
第一作者：
Qian,Yang
第一单位：
In vitro ADMET Laboratories LLC, 9221 Rumsey Road, Columbia, MD 21045, USA.
作者：
主题词
生物制品(Biological Products);细胞培养技术(Cell Culture Techniques);细胞, 培养的(Cells, Cultured);细胞色素P450酶系统(Cytochrome P-450 Enzyme System);减量调节(Down-Regulation);药物评价, 临床前(Drug Evaluation, Preclinical);女(雌)性(Female);基因表达调控, 酶学(Gene Expression Regulation, Enzymologic);肝细胞(Hepatocytes);人类(Humans);白细胞介素6(Interleukin-6);同工酶类(Isoenzymes);膜转运蛋白质类(Membrane Transport Proteins);中年人(Middle Aged);时间因素(Time Factors)
DOI
10.2174/138920012802138570
PMID
22475270
发布时间
2021-12-03
- 浏览27
Current drug metabolism
938-46页
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
