Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes.
第一作者:
Anders H,Rosengren
第一单位:
Lund University Diabetes Centre, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden. anders.rosengren@med.lu.se
作者:
医学主题词
细胞, 培养的(Cells, Cultured);糖尿病, 2型(Diabetes Mellitus, Type 2);胞吐作用(Exocytosis);疾病遗传易感性(Genetic Predisposition to Disease);遗传变异(Genetic Variation);葡萄糖转运体2型(Glucose Transporter Type 2);同源盒结构域蛋白质类(Homeodomain Proteins);人类(Humans);胰岛素(Insulin);胰岛素分泌细胞(Insulin-Secreting Cells);KCNQ1钾通道(KCNQ1 Potassium Channel);钾通道, 内向整流(Potassium Channels, Inwardly Rectifying);受体, 肾上腺素能α2(Receptors, Adrenergic, alpha-2);转录因子7样2蛋白(Transcription Factor 7-Like 2 Protein);转录因子(Transcription Factors)
DOI
10.2337/db11-1516
PMID
22492527
发布时间
2025-05-29
基金项目
095531/Z/11Z/WT_/Wellcome Trust/United Kingdom
MRC81696/MRC_/Medical Research Council/United Kingdom
095531/Z/11/Z/WT_/Wellcome Trust/United Kingdom
090532/WT_/Wellcome Trust/United Kingdom
095101/Z/10/Z/WT_/Wellcome Trust/United Kingdom
095101/WT_/Wellcome Trust/United Kingdom
095531/WT_/Wellcome Trust/United Kingdom
G0801995/MRC_/Medical Research Council/United Kingdom
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Diabetes
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