Development of selective estrogen receptor modulator (SERM)-like activity through an indirect mechanism of estrogen receptor antagonism: defining the binding mode of 7-oxabicyclo[2.2.1]hept-5-ene scaffold core ligands.
作者:
主题词
结合部位(Binding Sites);计算机模拟(Computer Simulation);结晶学, X线(Crystallography, X-Ray);环庚烷类(Cycloheptanes);Hep G2细胞(Hep G2 Cells);人类(Humans);配体(Ligands);蛋白质结构, 三级(Protein Structure, Tertiary);受体, 雌激素(Receptors, Estrogen);选择性雌激素受体调节剂(Selective Estrogen Receptor Modulators);构效关系(Structure-Activity Relationship);转录, 遗传(Transcription, Genetic);转染(Transfection)
DOI
10.1002/cmdc.201200048
PMID
22517684
发布时间
2021-10-21
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ChemMedChem
1094-100页
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