换一批Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma.
第一作者：
Naoya,Mimura
第一单位：
Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
作者：
医学主题词
动物(Animals);抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);苯醌类(Benzoquinones);骨髓细胞(Bone Marrow Cells);硼酸化物(Boronic Acids);细胞死亡(Cell Death);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);DNA结合蛋白质类(DNA-Binding Proteins);内切核糖核酸酶类(Endoribonucleases);酶激活(Enzyme Activation);酶抑制剂(Enzyme Inhibitors);人类(Humans);白细胞介素6(Interleukin-6);内酰胺类, 大环(Lactams, Macrocyclic);小鼠(Mice);多发性骨髓瘤(Multiple Myeloma);吡嗪类(Pyrazines);RNA剪接(RNA Splicing);RNA, 信使(RNA, Messenger);信号传导(Signal Transduction);间质细胞(Stromal Cells);转录因子(Transcription Factors);非折叠蛋白质应答(Unfolded Protein Response);eIF-2激酶(eIF-2 Kinase)
DOI
10.1182/blood-2011-07-366633
PMID
22538852
发布时间
2021-12-03
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Blood
5772-81页
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