Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors.
第一作者:
Lin,Chu
第一单位:
Discovery and Preclinical Sciences, Merck Research Laboratories, Rahway, NJ 07065, USA. lin_chu@merck.com
作者:
主题词
5-脂氧合酶活化蛋白抑制剂(5-Lipoxygenase-Activating Protein Inhibitors);5-脂氧合酶活化蛋白类(5-Lipoxygenase-Activating Proteins);烷烃类(Alkanes);动物(Animals);抗变态反应药(Anti-Allergic Agents);苯衍生物(Benzene Derivatives);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);注射, 静脉内(Injections, Intravenous);中性白细胞(Neutrophils);大鼠(Rats);立体异构现象(Stereoisomerism);构效关系(Structure-Activity Relationship)
DOI
10.1016/j.bmcl.2012.04.064
PMID
22578458
发布时间
2012-05-29
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