Preclinical and clinical studies of estrogen deprivation support the PDGF/Abl pathway as a novel therapeutic target for overcoming endocrine resistance in breast cancer.
作者:
主题词
芳香酶抑制剂(Aromatase Inhibitors);乳腺肿瘤(Breast Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);雌激素类(Estrogens);女(雌)性(Female);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);肿瘤辅助疗法(Neoadjuvant Therapy);肿瘤蛋白质类(Neoplasm Proteins);腈类(Nitriles);血小板源性生长因子(Platelet-Derived Growth Factor);蛋白酪氨酸激酶类(Protein-Tyrosine Kinases);原癌基因蛋白质c-abl(Proto-Oncogene Proteins c-abl);嘧啶类(Pyrimidines);RNA干扰(RNA Interference);RNA, 小分子干扰(RNA, Small Interfering);受体, 血小板源生长因子β(Receptor, Platelet-Derived Growth Factor beta);受体, 雌激素(Receptors, Estrogen);信号传导(Signal Transduction);三唑类(Triazoles)
DOI
10.1186/bcr3191
PMID
22608253
发布时间
2022-03-16
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