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Discovery of novel PI3-kinase δ specific inhibitors for the treatment of rheumatoid arthritis: taming CYP3A4 time-dependent inhibition.

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第一作者： Brian S,Safina

第一单位： Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States. bsafina@gene.com

作者： Brian S,Safina ^[1] ; Stewart,Baker ; Matt,Baumgardner ; Paul M,Blaney ; Bryan K,Chan ; Yung-Hsiang,Chen ; Matthew W,Cartwright ; Georgette,Castanedo ; Christine,Chabot ; Arnaud J,Cheguillaume ; Paul,Goldsmith ; David M,Goldstein ; Bindu,Goyal ; Timothy,Hancox ; Raj K,Handa ; Pravin S,Iyer ; Jasmit,Kaur ; Rama,Kondru ; Jane R,Kenny ; Sussie L,Krintel ; Jun,Li ; John,Lesnick ; Matthew C,Lucas ; Cristina,Lewis ; Sophie,Mukadam ; Jeremy,Murray ; Alan J,Nadin ; Jim,Nonomiya ; Fernando,Padilla ; Wylie S,Palmer ; Jodie,Pang ; Neil,Pegg ; Steve,Price ; Karin,Reif ; Laurent,Salphati ; Pascal A,Savy ; Eileen M,Seward ; Stephen,Shuttleworth ; Sukhjit,Sohal ; Zachary K,Sweeney ; Suzanne,Tay ; Parcharee,Tivitmahaisoon ; Bohdan,Waszkowycz ; Binqing,Wei ; Qin,Yue ; Chenghong,Zhang ; Daniel P,Sutherlin

作者单位： Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States. bsafina@gene.com ^[1]