Intranasal inoculation with an adenovirus vaccine encoding ten repeats of Aβ3-10 reduces AD-like pathology and cognitive impairment in Tg-APPswe/PSEN1dE9 mice.
第一作者:
Yu,Li
第一单位:
Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, Liao Ning Province, China.
作者:
主题词
腺病毒科(Adenoviridae);佐剂, 免疫(Adjuvants, Immunologic);投药, 鼻内(Administration, Intranasal);阿尔茨海默病(Alzheimer Disease);阿尔茨海默疫苗(Alzheimer Vaccines);淀粉样β肽类(Amyloid beta-Peptides);动物(Animals);脑(Brain);认知障碍(Cognition Disorders);CpG岛(CpG Islands);疾病模型, 动物(Disease Models, Animal);酶联免疫吸附测定(Enzyme-Linked Immunosorbent Assay);遗传载体(Genetic Vectors);免疫组织化学(Immunohistochemistry);男(雄)性(Male);迷宫学习(Maze Learning);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);肽碎片(Peptide Fragments)
DOI
10.1016/j.jneuroim.2012.04.014
PMID
22626444
发布时间
2012-07-06
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