换一批Intermittent PTH (1-34) injection rescues the retarded skeletal development and postnatal lethality of mice mimicking human achondroplasia and thanatophoric dysplasia.
第一作者：
Yangli,Xie
第一单位：
State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
作者：
医学主题词
软骨发育不全(Achondroplasia);动物(Animals);体重(Body Weight);骨密度(Bone Density);骨密度保护剂(Bone Density Conservation Agents);骨发育(Bone Development);骨疾病, 代谢性(Bone Diseases, Metabolic);骨和骨组织(Bone and Bones);细胞分化(Cell Differentiation);细胞增殖(Cell Proliferation);细胞, 培养的(Cells, Cultured);软骨细胞(Chondrocytes);药物评价, 临床前(Drug Evaluation, Preclinical);基因表达(Gene Expression);基因表达调控(Gene Expression Regulation);人类(Humans);肢芽(Limb Buds);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);突变, 误义(Mutation, Missense);甲状旁腺激素相关蛋白质(Parathyroid Hormone-Related Protein);放射摄影术(Radiography);受体, 成纤维细胞生长因子, 3型(Receptor, Fibroblast Growth Factor, Type 3);甲状旁腺激素肽(1-34)(Teriparatide);致死性发育不良(Thanatophoric Dysplasia);组织培养技术(Tissue Culture Techniques)
DOI
10.1093/hmg/dds181
PMID
22634226
发布时间
2016-11-25
- 浏览38
Human molecular genetics
3941-55页
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