换一批
换一批Inhibition of histone deacetylation potentiates the evolution of acquired temozolomide resistance linked to MGMT upregulation in glioblastoma xenografts.
第一作者：
Gaspar J,Kitange
第一单位：
Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA. kitange.gaspar@mayo.edu
作者：
主题词
乙酰化作用(Acetylation);动物(Animals);抗肿瘤药, 烷基化(Antineoplastic Agents, Alkylating);印迹法, 蛋白质(Blotting, Western);DNA甲基化(DNA Methylation);DNA修饰甲基酶类(DNA Modification Methylases);DNA修复酶类(DNA Repair Enzymes);达卡巴嗪(Dacarbazine);抗药性, 肿瘤(Drug Resistance, Neoplasm);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);胶质母细胞瘤(Glioblastoma);组蛋白脱乙酰基酶抑制剂(Histone Deacetylase Inhibitors);组蛋白类(Histones);人类(Humans);羟肟酸类(Hydroxamic Acids);Kaplan-Meiers评估(Kaplan-Meier Estimate);甲基化(Methylation);小鼠(Mice);启动区, 遗传(Promoter Regions, Genetic);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);肿瘤抑制蛋白质类(Tumor Suppressor Proteins);增量调节(Up-Regulation);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1158/1078-0432.CCR-12-0560
PMID
22675172
发布时间
2021-10-21
- 浏览20
Clinical cancer research
4070-9页
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