Palytoxin and an Ostreopsis toxin extract increase the levels of mRNAs encoding inflammation-related proteins in human macrophages via p38 MAPK and NF-κB.
作者:
主题词
丙烯酰胺类(Acrylamides);细胞核(Cell Nucleus);细胞形状(Cell Shape);细胞存活(Cell Survival);色谱法, 液相(Chromatography, Liquid);腔肠动物毒液类(Cnidarian Venoms);复合混合物(Complex Mixtures);环氧化酶2(Cyclooxygenase 2);基因表达调控(Gene Expression Regulation);人类(Humans);I-κB蛋白质类(I-kappa B Proteins);炎症(Inflammation);白细胞介素8(Interleukin-8);溶酶体(Lysosomes);MAP激酶信号系统(MAP Kinase Signaling System);巨噬细胞(Macrophages);海生毒素类(Marine Toxins);质谱分析法(Mass Spectrometry);单核细胞(Monocytes);NF-κB(NF-kappa B);肽水解酶类(Peptide Hydrolases);蛋白质转运(Protein Transport);RNA, 信使(RNA, Messenger);转录因子RelA(Transcription Factor RelA);肿瘤坏死因子α(Tumor Necrosis Factor-alpha);p38丝裂原活化蛋白激酶类(p38 Mitogen-Activated Protein Kinases)
DOI
10.1371/journal.pone.0038139
PMID
22675515
发布时间
2021-10-21
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