Genetic risk score constructed using 14 susceptibility alleles for type 2 diabetes is associated with the early onset of diabetes and may predict the future requirement of insulin injections among Japanese individuals.
第一作者:
Minoru,Iwata
第一单位:
First Department of Internal Medicine, Faculty of Medicine, Toyama University, Toyama, Japan. iwamino-tym@umin.ac.jp
作者:
主题词
衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);发病年龄(Age of Onset);老年人(Aged);等位基因(Alleles);阳离子转运蛋白质类(Cation Transport Proteins);细胞周期蛋白依赖激酶5(Cyclin-Dependent Kinase 5);周期素依赖激酶抑制剂p15(Cyclin-Dependent Kinase Inhibitor p15);糖尿病, 2型(Diabetes Mellitus, Type 2);女(雌)性(Female);疾病遗传易感性(Genetic Predisposition to Disease);同源盒结构域蛋白质类(Homeodomain Proteins);人类(Humans);胰岛素(Insulin);胰岛素受体底物蛋白质类(Insulin Receptor Substrate Proteins);KCNQ1钾通道(KCNQ1 Potassium Channel);男(雄)性(Male);中年人(Middle Aged);PPARγ(PPAR gamma);多态性, 单核苷酸(Polymorphism, Single Nucleotide);钾通道, 内向整流(Potassium Channels, Inwardly Rectifying);蛋白质类(Proteins);转录因子7样2蛋白(Transcription Factor 7-Like 2 Protein);转录因子(Transcription Factors);泛素缀合酶类(Ubiquitin-Conjugating Enzymes);tRNA甲基转移酶类(tRNA Methyltransferases)
DOI
10.2337/dc11-2006
PMID
22688542
发布时间
2022-12-07
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Diabetes care
1763-70页
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