Sphingosine-1-phosphate activates chemokine-promoted myeloma cell adhesion and migration involving α4β1 integrin function.
作者:
主题词
动物(Animals);骨髓(Bone Marrow);细胞黏附(Cell Adhesion);细胞形状(Cell Shape);趋化因子CXCL12(Chemokine CXCL12);共同培养技术(Coculture Techniques);GTP酶激活蛋白质类(GTPase-Activating Proteins);鸟嘌呤核苷酸交换因子类(Guanine Nucleotide Exchange Factors);人类(Humans);整合素α4β1(Integrin alpha4beta1);整合素α5β1(Integrin alpha5beta1);K562细胞(K562 Cells);溶血磷脂素类(Lysophospholipids);小鼠(Mice);小鼠, 近交NOD(Mice, Inbred NOD);小鼠, SCID(Mice, SCID);多发性骨髓瘤(Multiple Myeloma);RNA干扰(RNA Interference);受体, 鞘磷脂(Receptors, Lysosphingolipid);信号传导(Signal Transduction);鞘氨醇(Sphingosine);间质细胞(Stromal Cells);踝蛋白(Talin);时间因素(Time Factors);跨内皮和跨上皮迁移(Transendothelial and Transepithelial Migration);转染(Transfection);肿瘤细胞, 培养的(Tumor Cells, Cultured);血管细胞黏附分子1(Vascular Cell Adhesion Molecule-1);rac1 GTP结合蛋白质(rac1 GTP-Binding Protein)
DOI
10.1002/path.4066
PMID
22711564
发布时间
2020-12-09
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