Long-term proteasomal inhibition in transgenic mice by UBB(+1) expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients.
第一作者:
Martin,Irmler
第一单位:
Helmholtz Zentrum München, National Research Center for Environment and Health, GmbH, Institute of Experimental Genetics, Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany.
作者:
医学主题词
老年人(Aged);老年人, 80以上(Aged, 80 and over);阿尔茨海默病(Alzheimer Disease);动物(Animals);脑干(Brain Stem);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);人类(Humans);男(雄)性(Male);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);中年人(Middle Aged);神经元(Neurons);表型(Phenotype);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);呼吸(Respiration);泛素(Ubiquitin)
DOI
10.1007/s00401-012-1003-7
PMID
22730000
发布时间
2021-10-21
- 浏览98
Acta neuropathologica
187-97页
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