Reduced efficacy of the Plk1 inhibitor BI 2536 on the progression of hepatocellular carcinoma due to low intratumoral drug levels.
作者:
主题词
动物(Animals);抗肿瘤药(Antineoplastic Agents);癌, 肝细胞(Carcinoma, Hepatocellular);细胞周期蛋白质类(Cell Cycle Proteins);细胞系, 肿瘤(Cell Line, Tumor);细胞转化, 肿瘤(Cell Transformation, Neoplastic);疾病恶化(Disease Progression);抗药性, 肿瘤(Drug Resistance, Neoplasm);人类(Humans);肝(Liver);肝肿瘤(Liver Neoplasms);磁共振成像(Magnetic Resonance Imaging);男(雄)性(Male);小鼠(Mice);小鼠, 裸(Mice, Nude);小鼠, 转基因(Mice, Transgenic);蛋白激酶抑制剂(Protein Kinase Inhibitors);原癌基因蛋白质类(Proto-Oncogene Proteins);蝶啶类(Pteridines)
DOI
10.1596/neo.111366
PMID
22745587
发布时间
2023-12-13
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