Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model.
第一作者:
Sridhar R,Chirasani
第一单位:
Department of Neurology, University Medical Centre of Regensburg, Regensburg, Germany.
作者:
医学主题词
动物(Animals);消炎药, 非甾类(Anti-Inflammatory Agents, Non-Steroidal);骨髓细胞(Bone Marrow Cells);脑肿瘤(Brain Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);树突细胞(Dendritic Cells);二氯酚酸(Diclofenac);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);神经胶质瘤(Glioma);咪唑类(Imidazoles);免疫耐受(Immune Tolerance);干扰素γ(Interferon-gamma);白细胞介素10(Interleukin-10);白细胞介素12(Interleukin-12);白细胞介素2受体α亚单位(Interleukin-2 Receptor alpha Subunit);同工酶类(Isoenzymes);L-乳酸脱氢酶(L-Lactate Dehydrogenase);乳酸(Lactic Acid);淋巴细胞活化(Lymphocyte Activation);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);磷酰化(Phosphorylation);T淋巴细胞, 调节性(T-Lymphocytes, Regulatory);转录激活(Transcriptional Activation);增量调节(Up-Regulation)
DOI
10.1002/ijc.27712
PMID
22752934
发布时间
2019-12-10
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