Quiescent keratocytes fail to repair MMC induced DNA damage leading to the long-term inhibition of myofibroblast differentiation and wound healing.
第一作者:
James V,Jester
第一单位:
Gavin Herbert Eye Institute, University of California-Irvine, CA, USA. jjester@uci.edu
作者:
医学主题词
肌动蛋白类(Actins);动物(Animals);细胞分化(Cell Differentiation);细胞增殖(Cell Proliferation);细胞, 培养的(Cells, Cultured);趋化因子CCL2(Chemokine CCL2);瘢痕(Cicatrix);彗星试验(Comet Assay);角膜(Cornea);培养基, 无血清(Culture Media, Serum-Free);DNA损伤(DNA Damage);DNA修复(DNA Repair);组蛋白类(Histones);丝裂霉素(Mitomycin);肌成纤维细胞(Myofibroblasts);兔(Rabbits);转录, 遗传(Transcription, Genetic);转化生长因子β(Transforming Growth Factor beta);伤口愈合(Wound Healing)
PMID
22815636
发布时间
2021-10-21
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Molecular vision
1828-39页
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