(+)-Episesamin inhibits adipogenesis and exerts anti-inflammatory effects in 3T3-L1 (pre)adipocytes by sustained Wnt signaling, down-regulation of PPARγ and induction of iNOS.
作者:
主题词
3T3-L1细胞(3T3-L1 Cells);脂细胞(Adipocytes);成脂分化(Adipogenesis);动物(Animals);消炎药(Anti-Inflammatory Agents);半胱氨酸天冬氨酸蛋白酶3(Caspase 3);半胱氨酸天冬氨酸蛋白酶7(Caspase 7);细胞分化(Cell Differentiation);二恶茂类(Dioxoles);减量调节(Down-Regulation);葡萄糖转运体4型(Glucose Transporter Type 4);炎症(Inflammation);白细胞介素6(Interleukin-6);木酚素类(Lignans);山胡椒属(Lindera);脂类代谢(Lipid Metabolism);肝(Liver);小鼠(Mice);一氧化氮合酶Ⅱ型(Nitric Oxide Synthase Type II);肥胖症(Obesity);PPARγ(PPAR gamma);磷酰化(Phosphorylation);植物提取物(Plant Extracts);Toll样受体4(Toll-Like Receptor 4);肿瘤坏死因子α(Tumor Necrosis Factor-alpha);血管内皮生长因子A(Vascular Endothelial Growth Factor A);β连环素(beta Catenin)
DOI
10.1016/j.jnutbio.2012.02.004
PMID
22818712
发布时间
2013-03-04
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