Endogenous concentrations of ouabain act as a cofactor to stimulate fluid secretion and cyst growth of in vitro ADPKD models via cAMP and EGFR-Src-MEK pathways.
作者:
主题词
动物(Animals);细胞增殖(Cell Proliferation);细胞, 培养的(Cells, Cultured);环AMP(Cyclic AMP);囊肿(Cysts);上皮细胞(Epithelial Cells);人类(Humans);肾(Kidney);小鼠(Mice);哇巴因(Ouabain);多囊肾, 常染色体显性(Polycystic Kidney, Autosomal Dominant);信号传导(Signal Transduction)
DOI
10.1152/ajprenal.00677.2011
PMID
22859406
发布时间
2024-06-30
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