换一批Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships.
第一作者：
Karen J,Gregory
第一单位：
Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
作者：
医学主题词
别构调节(Allosteric Regulation);别构部位(Allosteric Site);动物(Animals);钙(Calcium);谷氨酸(Glutamic Acid);HEK293细胞(HEK293 Cells);人类(Humans);丝裂原活化蛋白激酶1(Mitogen-Activated Protein Kinase 1);丝裂原活化蛋白激酶3(Mitogen-Activated Protein Kinase 3);磷酰化(Phosphorylation);点突变(Point Mutation);放射配体测定(Radioligand Assay);大鼠(Rats);受体, 亲代谢性谷氨酸盐(Receptors, Metabotropic Glutamate);构效关系(Structure-Activity Relationship)
DOI
10.1124/mol.112.080531
PMID
22863693
发布时间
2025-02-13
基金项目
F32-NS071746/NS/NINDS NIH HHS/United States
R01 MH062646/MH/NIMH NIH HHS/United States
U54 MH084659/MH/NIMH NIH HHS/United States
R01 NS031373/NS/NINDS NIH HHS/United States
1R01-DA023947/DA/NIDA NIH HHS/United States
5U54-MH84659-03/MH/NIMH NIH HHS/United States
F32 MH088234/MH/NIMH NIH HHS/United States
F32-MH088234-02/MH/NIMH NIH HHS/United States
U19 MH097056/MH/NIMH NIH HHS/United States
5U54-MH84659-03S1/MH/NIMH NIH HHS/United States
2R01-NS031373-16A2/NS/NINDS NIH HHS/United States
F32 NS071746/NS/NINDS NIH HHS/United States
2R01-MH062646-13/MH/NIMH NIH HHS/United States
R01 DA023947/DA/NIDA NIH HHS/United States
- 浏览91
Molecular pharmacology
860-75页
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