Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives.-论文-万方医学网

作者： Masaaki,Hirose ^[1] ; Masanori,Okaniwa ; Tohru,Miyazaki ; Takashi,Imada ; Tomohiro,Ohashi ; Yuta,Tanaka ; Takeo,Arita ; Masato,Yabuki ; Tomohiro,Kawamoto ; Shunichirou,Tsutsumi ; Akihiko,Sumita ; Terufumi,Takagi ; Bi-Ching,Sang ; Jason,Yano ; Kathleen,Aertgeerts ; Sei,Yoshida ; Tomoyasu,Ishikawa

作者单位： Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited: 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan. masaaki.hirose@takeda.com ^[1]

主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞增殖(Cell Proliferation);结晶学, X线(Crystallography, X-Ray);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物设计(Drug Design);HT29细胞(HT29 Cells);人类(Humans);小鼠(Mice);微粒体(Microsomes);模型, 分子(Models, Molecular);分子结构(Molecular Structure);肿瘤, 实验性(Neoplasms, Experimental);蛋白激酶抑制剂(Protein Kinase Inhibitors);大鼠(Rats);大鼠, 近交F344(Rats, Inbred F344);构效关系(Structure-Activity Relationship);噻唑类(Thiazoles);血管内皮生长因子受体2(Vascular Endothelial Growth Factor Receptor-2);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1016/j.bmc.2012.07.032

PMID 22883026

发布时间 2012-09-17

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Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives.

Bioorganic & medicinal chemistry

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Bioorganic & medicinal chemistry

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Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives.

Bioorganic & medicinal chemistry

相似文献

Bioorganic & medicinal chemistry

相关期刊

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