换一批In vitro characterisation of the novel positive allosteric modulators of the mGlu₅ receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat.
第一作者：
Gary,Gilmour
第一单位：
Eli Lilly & Company Ltd., Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, United Kingdom. GILMOUR_GARY@LILLY.COM
作者：
医学主题词
别构调节(Allosteric Regulation);动物(Animals);觉醒(Arousal);行为, 动物(Behavior, Animal);细胞系(Cell Line);细胞, 培养的(Cells, Cultured);大脑皮质(Cerebral Cortex);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物, 临床试用(Drugs, Investigational);胚胎, 哺乳动物(Embryo, Mammalian);兴奋性氨基酸激动剂(Excitatory Amino Acid Agonists);人类(Humans);男(雄)性(Male);神经元(Neurons);脑代谢改善药(Nootropic Agents);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);受体, 亲代谢性谷氨酸盐(Receptors, Metabotropic Glutamate);重组蛋白质类(Recombinant Proteins);精神分裂症(Schizophrenia);睡眠期(Sleep Stages);组织分布(Tissue Distribution)
DOI
10.1016/j.neuropharm.2012.07.030
PMID
22884720
发布时间
2013-11-21
- 浏览10
Neuropharmacology
224-39页
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