Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK.

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第一作者： Antonio,Maraver

第一单位： Tumor Suppression Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain.

作者： Antonio,Maraver ^[1] ; Pablo J,Fernández-Marcos ^[1] ; Daniel,Herranz ^[1] ; Maribel,Muñoz-Martin ^[2] ; Gonzalo,Gomez-Lopez ^[1] ; Marta,Cañamero ^[3] ; Francisca,Mulero ^[4] ; Diego,Megías ^[5] ; Marta,Sanchez-Carbayo ^[6] ; Jie,Shen ^[7] ; Montserrat,Sanchez-Cespedes ^[8] ; Teresa,Palomero ^[9] ; Adolfo,Ferrando ^[2] ; Manuel,Serrano ^[2]

作者单位： Tumor Suppression Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain. ^[1] Institute of Cancer Genetics, Columbia University Medical Center, New York, NY, USA. ^[2] Bioinformatics Unit, Spanish National Cancer Research Center (CNIO), Madrid, Spain. ^[3] Comparative Pathology Unit, Spanish National Cancer Research Center (CNIO), Madrid, Spain. ^[4] Molecular Imaging Unit, Spanish National Cancer Research Center (CNIO), Madrid, Spain. ^[5] Confocal Microscopy Unit, Spanish National Cancer Research Center (CNIO), Madrid, Spain. ^[6] Tumor Markers Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain. ^[7] Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. ^[8] Cancer Epigenetics and Biology Program - IDIBELL, Barcelona, Spain. ^[9]