换一批The transcription factor Wilms tumor 1 confers resistance in myeloid leukemia cells against the proapoptotic therapeutic agent TRAIL (tumor necrosis factor α-related apoptosis-inducing ligand) by regulating the antiapoptotic protein Bcl-xL.
第一作者：
Hima,Bansal
第一单位：
Greehey Children's Cancer Research Institute, The University of Texas Health Science Center, San Antonio, Texas 78229, USA.
作者：
医学主题词
细胞凋亡(Apoptosis);抗药性, 肿瘤(Drug Resistance, Neoplasm);基因表达调控, 白血病(Gene Expression Regulation, Leukemic);基因敲低技术(Gene Knockdown Techniques);人类(Humans);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);TNF相关凋亡诱导配体(TNF-Related Apoptosis-Inducing Ligand);WT1蛋白质类(WT1 Proteins);bcl-X蛋白质(bcl-X Protein)
DOI
10.1074/jbc.C112.366559
PMID
22898820
发布时间
2021-10-21
基金项目
R01 HD057118/HD/NICHD NIH HHS/United States
HD057118/HD/NICHD NIH HHS/United States
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