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A screen for inducers of p21(waf1/cip1) identifies HIF prolyl hydroxylase inhibitors as neuroprotective agents with antitumor properties.

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第一作者： Thong C,Ma

第一单位： Burke-Cornell Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA; Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10065, USA. Electronic address: tma@burke.org.

作者： Thong C,Ma ^[1] ; Brett,Langley ^[2] ; Brian,Ko ^[2] ; Na,Wei ^[3] ; Irina G,Gazaryan ^[2] ; Neela,Zareen ^[4] ; Darrell J,Yamashiro ^[3] ; Dianna E,Willis ^[2] ; Rajiv R,Ratan ^[5]

作者单位： Burke-Cornell Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA; Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10065, USA. Electronic address: tma@burke.org. ^[1] Burke-Cornell Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA; Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10065, USA. ^[2] Department of Pediatrics, Pathology, and Cell Biology, Columbia University College of Physicians and Surgeons, 161 Fort Washington Avenue, New York, NY 10032, USA. ^[3] Department of Pathology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY, 10032, USA. ^[4] Burke-Cornell Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA; Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10065, USA. Electronic address: rratan@burke.org. ^[5]

关键词 Antitumor Neuronal oxidative stress Neuroprotection Prolyl hydroxylase inhibitors p21