换一批Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression.
第一作者：
Loredana,Ciuclan
第一单位：
Respiratory Disease Area, Novartis Institutes for BioMedical Research, Horsham, West Sussex, UK.
作者：
医学主题词
动物(Animals);苯甲酰胺类(Benzamides);疾病模型, 动物(Disease Models, Animal);血流动力学(Hemodynamics);高血压, 肺性(Hypertension, Pulmonary);吲哚类(Indoles);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);磷酰化(Phosphorylation);哌嗪类(Piperazines);蛋白激酶抑制剂(Protein Kinase Inhibitors);蛋白酪氨酸激酶类(Protein-Tyrosine Kinases);嘧啶类(Pyrimidines);吡咯类(Pyrroles);受体, 血小板源生长因子β(Receptor, Platelet-Derived Growth Factor beta);血清素(Serotonin);色氨酸羟化酶(Tryptophan Hydroxylase)
DOI
10.1164/rccm.201206-1028OC
PMID
23087024
发布时间
2025-05-29
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