换一批A perspective on the contribution of metabolites to drug-drug interaction potential: the need to consider both circulating levels and inhibition potency.
第一作者：
Hongbin,Yu
第一单位：
Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877, USA. hongbin.yu@boehringer-ingelheim.com
作者：
医学主题词
动物(Animals);曲线下面积(Area Under Curve);生物转化(Biotransformation);细胞色素P450酶系统(Cytochrome P-450 Enzyme System);决策树(Decision Trees);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物相互作用(Drug Interactions);酶抑制剂(Enzyme Inhibitors);人类(Humans);模型, 生物学(Models, Biological);模型, 统计学(Models, Statistical);分子结构(Molecular Structure);药用制剂(Pharmaceutical Preparations);危险性评估(Risk Assessment);构效关系(Structure-Activity Relationship)
DOI
10.1124/dmd.112.048892
PMID
23143892
发布时间
2025-02-12
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