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Serum-free culture of primary human hepatocytes in a miniaturized hollow-fibre membrane bioreactor for pharmacological in vitro studies.

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第一作者： Marc,Lübberstedt

第一单位： Bioreactor Group, Division of Experimental Surgery, Berlin Brandenburg Center for Regenerative Therapies (BCRT), Charité Universitätsmedizin, Berlin, Germany.

作者： Marc,Lübberstedt ^[1] ; Ursula,Müller-Vieira ^[2] ; Klaus M,Biemel ^[2] ; Malin,Darnell ^[3] ; Stefan A,Hoffmann ^[1] ; Fanny,Knöspel ^[1] ; Eva C,Wönne ^[1] ; Daniel,Knobeloch ^[4] ; Andreas K,Nüssler ^[5] ; Jörg C,Gerlach ^[6] ; Tommy B,Andersson ^[3] ; Katrin,Zeilinger ^[1]

作者单位： Bioreactor Group, Division of Experimental Surgery, Berlin Brandenburg Center for Regenerative Therapies (BCRT), Charité Universitätsmedizin, Berlin, Germany. ^[1] Pharmacelsus GmbH, Saarbrücken, Germany. ^[2] DMPK Innovative Medicines, AstraZeneca R&D, Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. ^[3] Cytonet GmbH & Co KG, Weinheim, Germany. ^[4] Department of Traumatology, Eberhard Karls University, Tübingen, Germany. ^[5] Departments of Surgery and of Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, USA. ^[6]

关键词 bioreactor cytochrome P450 human hepatocytes perfusion pharmacological studies serum-free three-dimensional culture