An engineered human follistatin variant: insights into the pharmacokinetic and pharmocodynamic relationships of a novel molecule with broad therapeutic potential.
第一作者:
Amita,Datta-Mannan
第一单位:
Department of Drug Disposition Development/Commercialization, Lilly Research Laboratories, Indianapolis, IN 46285, USA.
作者:
医学主题词
动物(Animals);细胞系(Cell Line);剂量效应关系, 药物(Dose-Response Relationship, Drug);卵泡抑素(Follistatin);HEK293细胞(HEK293 Cells);半衰期(Half-Life);肝素(Heparin);人类(Humans);免疫球蛋白G(Immunoglobulin G);配体(Ligands);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);肌萎缩(Muscular Atrophy);蛋白质结合(Protein Binding);蛋白质工程(Protein Engineering);重组蛋白质类(Recombinant Proteins);琼脂糖(Sepharose)
DOI
10.1124/jpet.112.201491
PMID
23249626
发布时间
2025-03-06
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