Silencing of RB1 but not of RB2/P130 induces cellular senescence and impairs the differentiation potential of human mesenchymal stem cells.
第一作者:
Nicola,Alessio
第一单位:
Department of Experimental Medicine, Biotechnology and Molecular Biology Section, Second University of Naples, Naples, Italy.
作者:
医学主题词
细胞凋亡(Apoptosis);细胞周期(Cell Cycle);细胞分化(Cell Differentiation);细胞, 培养的(Cells, Cultured);DNA损伤(DNA Damage);基因表达调控, 发育期(Gene Expression Regulation, Developmental);人类(Humans);间质干细胞(Mesenchymal Stem Cells);RNA干扰(RNA Interference);视网膜母细胞瘤蛋白质(Retinoblastoma Protein);视网膜母细胞瘤样蛋白质p130(Retinoblastoma-Like Protein p130);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53)
DOI
10.1007/s00018-012-1224-x
PMID
23370776
发布时间
2024-05-25
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