Different effects of clopidogrel and clarithromycin on the enantioselective pharmacokinetics of sibutramine and its active metabolites in healthy subjects.
第一作者:
Dhananjay D,Shinde
第一单位:
Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, South Korea.
作者:
主题词
成年人(Adult);食欲抑制药(Appetite Depressants);芳基烃羟化酶类(Aryl Hydrocarbon Hydroxylases);克拉霉素(Clarithromycin);交叉研究(Cross-Over Studies);环丁烷类(Cyclobutanes);细胞色素P-450 CYP3A(Cytochrome P-450 CYP3A);基因型(Genotype);人类(Humans);男(雄)性(Male);微粒体(Microsomes);氧化还原酶类, N-脱甲基(Oxidoreductases, N-Demethylating);多态现象, 遗传(Polymorphism, Genetic);立体异构现象(Stereoisomerism);噻氯匹定(Ticlopidine);青年人(Young Adult)
DOI
10.1002/jcph.69
PMID
23381968
发布时间
2018-12-02
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